Articles | Volume 12, issue 1
https://doi.org/10.5194/ms-12-501-2021
https://doi.org/10.5194/ms-12-501-2021
Research article
 | 
18 May 2021
Research article |  | 18 May 2021

Structure optimization of a pipetting device to improve the insertion effect of tips

Zeng Huang, Chenxue Wang, Qian Su, and Zhiping Lian

Related subject area

Subject: Machining and Manufacturing Processes | Techniques and Approaches: Mathematical Modeling and Analysis
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Cited articles

Allison, J., Bailey, D, M., Johnnie, W., and Mikesell, B.: An automatic micropipette fluid dispenser, Behav. Res. Meth. Ins. C., 22, 517–519, https://doi.org/10.3758/BF03204435, 1990. 
Chen, Z., Fang, Y., and Peng, J.: Design and Implementation of Temperature Acquisition System for Polymerase Chain Reaction, Journal of Bionanoscience, 9, 480–483, https://doi.org/10.1166/jbns.2015.1334, 2015. 
Dutka, F., Opalski, A, S., and Garstecki, P.: Nano-liter droplet libraries from a pipette: step emulsificator that stabilizes droplet volume against variation in flow rate, Lab Chip., 16, 2044–2049, https://doi.org/10.1039/c6lc00265j, 2016. 
Engström, K. and Meiselman, H. J.: Fabrication of glass micropipettes: A semi-automatic approach for trimming the pipette tip, Biorheology, 29, 499–506, https://doi.org/10.1016/j.biomaterials.2012.08.045, 1992. 
He, J.: Integration of Laboratory Automation Analyzer and Information System, China Digital Medicine., 06, 99–102, https://doi.org/10.3969/j.issn.1673-7571.2011.08.031, 2011. 
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Short summary
In this paper, a high-rigidity screw-type tip-inserting mechanism with a good centering effect is designed. The structural characteristics and working principle of the inserting mechanism are introduced, the stiffness model of the new-type pipetting device is established and its stiffness and axial deformation are calculated. Finally, a multi-station high-throughput automatic pipette produced by a company was used as an example to optimize and improve it and conduct a prototype test.